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The Best Mississippi River Cruises to Discover America's Heartland

By Jackie Sheckler Finch

The luxury ships and historic tours are nice, yes. But the real star of Mississippi River cruises has always been the river. There’s nothing quite so Americana as getting to know the many personalities of this 2,350-mile stretch, flowing from northern Minnesota’s Lake Itasca through 10 states until it reaches Louisiana , where the Mississippi River Delta gives way to the Gulf of Mexico.

The slow, meandering journeys of Mississippi River cruises have long proven an ideal way to discover the distinct stories of America’s heartland. In the words of Mark Twain (which no Mississippi River story would be complete without), the towns and cities located on the mighty river's shores are “cheering to the spirit” and “reposeful as a dreamland,” with “nothing to hang a fret or a worry upon.”

The challenge modern travelers now face is when, where, and how to go about this iconic American voyage . Below, see our answers to these frequently asked questions, plus our favorite Mississippi River cruises to book in 2024.

Which cruise lines do Mississippi River cruises?

After American Queen Voyages shut down in February, only two Mississippi River cruise lines currently remain in operation.

Celebrating its 50th anniversary, American Cruise Lines (ACL) has a fleet of more than 20 American-built ships sailing across the country and remains family-owned and American-crewed. ACL offers a Mississippi River fleet of three luxurious 180-passenger modern riverboats– American Melody , American Symphony , and American Serenade —plus two classic paddlewheel ships, the 180-passenger American Splendor and the 150-passenger American Heritage.

The new kid on the Mississippi is the Viking Mississippi, a 386-passenger, five-deck vessel that first set sail in September 2022. The cutting-edge cruise is Viking’s first foray in the US, adding to their fleet of more than 90 ocean, river, and expedition vessels navigating the world’s seven continents.

What is the average cost of a Mississippi River cruise?

For an 8- or 9-day cruise, the average cost of a Mississippi River cruise is around $4,000 per person in a stateroom. Although prices might seem high initially, many of these cruises include extras that aren’t always complimentary on ocean cruises such as free WiFi, at least one free shore excursion in every port, paid port taxes and fees, and a pre-cruise hotel stay. Viking offers complimentary beer, wine, and soft drinks with onboard lunch and dinner. Meanwhile, American Cruise Lines offers complimentary beer, wine, cocktails, and soft drinks. Gratuities are also included in American Cruise Lines fares.

What is the best time of year to go on a river cruise?

Spring (late March through mid-June) and autumn (September through November) are the best times of year to go on a river cruise in the US. Spring blossoms add a colorful touch to the shoreline, and you can never go wrong with autumn foliage. The temperatures are mild, if not pleasantly cool, and passengers are eager to welcome a new spring travel season—or to enjoy one last autumn river adventure before winter arrives.

What month is best for a Mississippi River cruise?

If we had to pick just one, September is the best month for a Mississippi River cruise. The weather is usually mild with less likelihood of rain, and autumn colors are beginning to paint the shoreline. Keep in mind, however, that the Mississippi is the fourth largest river in the world—so temperatures any time of year are not going to be the same in warmer Louisiana as they are in cooler Minnesota.

Below, see our favorite Mississippi River cruises to book in 2024, featuring stops in iconic American cities like Nashville , Memphis , and New Orleans .

22-day Mississippi River Odyssey: New Orleans to Red Wing, Minnesota

Enjoy the charms of America’s great river on a journey aboard the Viking Mississippi from New Orleans to Red Wing, departing September 20. Custom built to sail American waters, the vessel features river-facing staterooms with either French or step-out balconies.

Stops include Baton Rouge and St. Francisville in Louisiana; Natchez, Vicksburg, Greenville, and Rosedale in Mississippi; Memphis in Tennessee; Paducah in Kentucky; Cape Girardeau, St. Louis, and Hannibal in Missouri; Burlington, Quad Cities, and Dubuque in Iowa; La Crosse in Wisconsin; and ending in Red Wing, Minnesota.

With so many fascinating shore excursions to choose from, it’s well worth taking time to tour the St. Louis Arch . Opened in 1965, the monument to America’s westward expansion is far more than just a stunning photo by the riverside. Venture underground between the arch legs for a museum. Climb aboard a tram to be transported 630 feet up to the top of America’s tallest monument for some stunning views.

12-day Heart of the Delta: Memphis to New Orleans

The 386-guest Viking Mississippi spans five decks, making it one of the largest passenger vessels on the Mississippi. Inaugurated in 2022, the ship features a modern Scandinavian design with an infinity pool and a two-story Explorers’ Lounge observation area similar to its ocean ships. Directly in front of the Explorer’s Lounge is an expanded outdoor seating area known as The Bow. Three restaurants serve both Southern regional cuisine and international favorites.

The cruise starts in Memphis on November 14 and includes stops in Rosedale, Greenville, Vicksburg, and Natchez in Mississippi as well as St. Francisville, Baton Rouge, and Darrow in Louisiana, ending in New Orleans. The “Mississippi Sings the Blues” shore excursion visits iconic sites along the Mississippi Blues Trail such as historic Dockery Farms, considered the “birthplace of the blues.”

The tour stops in Clarksdale, the fabled “Crossroads” where legend says blues great Robert Johnson reputedly sold his soul to the devil in exchange for his guitar prowess. Stops at the GRAMMY Museum Mississippi and the Delta Blues Museum completes this perfect trip for music lovers.

9-day Music Cities Cruise: Nashville to Memphis

Music is the main focus of this cruise offered by American Cruise Lines, which begins in Nashville on July 9 with an unforgettable visit to the legendary Grand Ole Opry and ends in Memphis, where passengers will enjoy live music on Beale Street and a tour of Elvis Presley’s Graceland . On board the American Splendor, passengers will enjoy spacious cabins and popular rocking chairs. First inaugurated in 2016 and fully redecorated in 2022, this ship offers the nostalgia of a classic paddlewheeler along with the comfort of modern amenities.

While in Nashville, explore the Johnny Cash Museum, then walk upstairs to The Patsy Cline Museum. Nightly entertainment spotlights the musical heritage of this region as the world’s newest paddlewheeler journeys along the river. The itinerary also includes Clarksville and Dover in Tennessee plus Paducah in Kentucky. In Paducah, stroll along the riverfront with more than 50 life-sized panoramic murals depicting Paducah’s past. Stop by Paducah’s National Quilt Museum, the world’s largest museum devoted to quilt and fiber art.

23-day Complete Mississippi River Cruise: New Orleans to St. Paul

Sail 1,393 miles through 10 states on a comprehensive exploration of the mighty Mississippi on the new American Serenade . Inaugurated in 2023, the 91-cabin American Serenade won Best New River Cruise Ship of the Year 2023 by Cruise Critic , the first time an American ship has received this prestigious award.

“With extra-large all-balcony staterooms and suites, trendy interior décor, an innovative hydraulic bow and retractable ramp, and one of the most gorgeous sun decks we’ve seen on a river-going ship, American Serenade sets the bar for domestic US river cruising high,” the award notes.

The epic itinerary beginning July 18, 2024 includes 22 ports of call including Oak Alley, Houmas House, Baton Rouge, and St. Francisville in Louisiana; Natchez, Vicksburg, Greenville, and Tunica in Mississippi; Memphis in Tennessee; Cape Girardeau, St. Louis, and Hannibal in Missouri; Muscatine and Dubuque in Iowa; and Winona, Red Wing, and Saint Paul in Minnesota.

Olivia Morelli

Tony Perrottet

Jahnavi Bhatt

Federica Bocco

12-day Mississippi River Gateway Cruise: New Orleans to St. Louis

From the French Quarter in New Orleans to the towering Gateway Arch in St. Louis , this American Heritage cruise lives up to its name. Inaugurated in 2015 and totally redecorated in 2022, the 84-cabin American Heritage is the perfect vessel for this interesting itinerary, its design reminiscent of the days when steamboat paddlewheelers plied the Mississippi in the 1800s.

The 12-day voyage departs from New Orleans on July 2. Ports of call along the way include Baton Rouge in Louisiana; Natchez and Vicksburg in Mississippi; Memphis in Tennessee; and Paducah in Kentucky . An onboard expert shares tales of the importance of steam-driven paddlewheels in establishing riverfront communities along the great Mississippi River.

Step ashore in Natchez and enjoy a cold drink at the Under-the-Hill-Saloon, once one of the rowdiest establishments on the Mississippi River in the 1800s. Legend says that Mark Twain stopped here when he was just another riverman named Samuel Clemens.

9-day Lower Mississippi River Cruise: Memphis to New Orleans

This nine-day American Melody cruise departs Memphis on September 8 and features eight ports of call including Vicksburg and Natchez in Mississippi, and St. Francisville, Baton Rouge, and Houmas House in Louisiana. At Vicksburg Military Park, learn how the 101st Airborne Division got its “Screaming Eagles” nickname, plus the tale of its famous soldier, a young guitar player named Jimi Hendrix. At Houmas House, see the bedroom where Bette Davis stayed to film the 1964 movie Hush, Hush, Sweet Charlotte . Joan Crawford was the intended co-star but Bette and Joan feuded so Joan quit and Olivia de Havilland replaced her.

Launched in 2021, the five-deck American Melody has 91 staterooms, all with private balconies and full-length sliding glass doors. The ship has several spacious lounges, a fitness center, large dining room, café for casual dining, sun deck, library, and an impressive four-story glass atrium in the center of the ship. The ship’s unusual bow opens and lowers a platform for passengers to easily walk ashore.

9-day Upper Mississippi River Cruise: St. Louis to St. Paul

Board the American Symphony cruise ship to visit Mark Twain’s hometown and experience the real-life inspiration behind Life on the Mississippi, the classic memoir chronicling the author's days on the river as a steamboat pilot.

The 91-cabin American Symphony, recently inaugurated in 2022, has 100% private balcony accommodations and a unique bow that opens with a retractable gangway that can be extended for landings virtually anywhere. The ship also features lounges soaring 40 feet above the water with triple the glass of other riverboats for spectacular views. Comfy deck chairs welcome passengers to enjoy the undeveloped countryside, picturesque islands, and fascinating dams and navigation locks.

Departing September 27, this itinerary features seven ports of call including Muscatine and Dubuque in Iowa, and Winona and Red Wing in Minnesota. In Hannibal, visit the actual home—with a whitewashed Tom Sawyer fence—where Samuel Clemens (Mark Twain) grew up. In Dubuque, see the 1989 “Field of Dreams” movie site known for the famous quote, “If you build it, they will come.”

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The 7 best mississippi river cruises for 2024.

Explore the history, culture and cuisine of the U.S. while cruising along the Mighty Mississippi.

The Best Mississippi River Cruises

Courtesy of American Cruise Lines

The more than 2,300-mile Mississippi River invites travelers to discover its multifaceted heritage, with a vast range of deeply rooted culture, music and history. A cruise is a fantastic way to discover many of the riverfront cities on a single trip, from the comfort of your modern riverboat or traditional paddle-wheeler.

The following Mississippi River cruise itineraries can help you choose from cruises of various lengths and options for the Lower and Upper Mississippi. Note that all fares are listed as double occupancy (based on two people per cabin), and that they might not reflect taxes, port fees or gratuities. The itinerary availability listed is also subject to change.

American Cruise Lines

Courtesy of American Cruise Lines | www.AmericanCruiseLines.com

American Cruise Lines operates small ships accommodating between 90 and 180 passengers that are built, flagged and crewed in the U.S. – and it's the only company in the world operating a 100% U.S.-flagged fleet of riverboats and cruise ships. ACL's itineraries traverse waterways across 35 states, with 11 itineraries dedicated to the Mississippi River. Cruisers can choose to sail on modern riverboats with a sleek interior design or while away their time aboard classic paddle-wheelers reminiscent of days gone by.

ACL offers variety as well as versatility: This line boasts both the longest and shortest sailings on this list with cruises ranging from eight to 60 days in length, including The Great United States. This inaugural 60-day voyage spans four major rivers and 20 states, making it the longest U.S. river cruise in history.

Complimentary hotel and transportation packages are available from every departure city before your cruise. You can book certain premium packages for added perks, such as two nights spent next door to Graceland in Memphis – with VIP tickets and a city tour included in the price.

Music Cities Cruise

Length: Eight days Price: Starts at $3,610 per person

Spend a week getting lost in the sounds of the Memphis blues, rock 'n' roll and country music legends on the seven-night Music Cities Cruise. A hotel stay the night before your sailing is included, but embarking in Memphis means you also have the chance to splurge on a two-night pre-cruise package near Elvis' former home Graceland .

Ports of call include Paducah, Kentucky; Dover, Tennessee; and Clarksville, Tennessee, with an overnight in Nashville and an included excursion to a show at the Grand Ole Opry. Two scenic sailing days feature picturesque views of America's Heartland along the Mississippi, Ohio and Cumberland rivers as well as Lake Barkley.

2024 dates: In 2024, there are two available itineraries in September and November.

Grand Heartland Cruise: St. Paul to New Orleans

Length: 15 days Price: Starts at $9,455 per person

This 15-day voyage allows you to explore America's rich history in towns along the Upper and Lower Mississippi River. The immersive voyage covers six states and 12 cities including St. Paul, Minnesota ; Dubuque, Iowa; St. Louis, Missouri ; Memphis, Tennessee; Natchez, Mississippi; Baton Rouge, Louisiana ; and more.

Take a step back in time while visiting Mark Twain's boyhood home in Hannibal, exploring stately historic estates in Natchez and Civil War sites in Vicksburg. At the end of a busy day ashore, you'll have plenty to chat about with fellow passengers during the evening cocktail hour.

2024 dates: American Heritage – ACL's traditional paddle-wheeler – and three modern riverboats set off on this journey from August to October in 2024.

Complete Mississippi River Cruise: New Orleans to St. Paul

Length: 22 days Price: Starts at $14,935 per person

If you want to see the entire Mississippi in one shot, check out this multiweek sailing that begins in New Orleans and ends in St. Paul, Minnesota. Along the way, you'll sail 1,393 miles, visit 10 states and experience a staggering 20 ports of call as you tour Louisiana and then head northbound to Minnesota.

In the South, walk the battlefields of the Civil War and sample delicious Southern barbecue before listening to the rhythms of jazz, the blues and rock 'n' roll. Then, explore the small and larger cities along the upper parts of the river. Remember to take time to gaze out at the picturesque scenery and the rolling farmlands of America's Midwest before disembarking in St. Paul.

2024 dates: Three of ACL's modern riverboats sail this itinerary in May, June and August in 2024.

The Great United States

Length: 60 days Price: Starts at $51,000

This two-month long journey – the longest domestic itinerary ever created – will check all the boxes for U.S. history and Civil War buffs, music and nature lovers, culinary enthusiasts, and beer and distilled spirits aficionados alike as the ship traverses America's iconic waterways through 20 states and 50 ports of call.

This epic journey showcases the natural beauty and living history of the U.S. from sea to shining sea. The sailing embarks in Portland, Oregon , on the Pacific Coast before traveling east to the Atlantic shore along four major rivers that highlight some of the country's most stunning coastlines. Upon arrival in New York Harbor, guests will have an unforgettable view of one of the most iconic landmarks in the U.S.: the Statue of Liberty .

Passengers can follow in the footsteps of Lewis and Clark along the Snake and Columbia rivers; cruise along Ol' Man River in search of Mark Twain and Elvis; see the vibrant colors of fall during peak season on the Hudson River; and take in the coastal breezes (and fresh seafood) along New England's rocky coastline.

This curated adventure also includes two flights: Jackson, Wyoming , to New Orleans as well as St. Paul to Portland, Maine , plus a land package through Glacier , Yellowstone and Grand Teton national parks. All-inclusive pricing covers the pre-cruise hotel stay, all flights and hotels between cruise segments, an ACL jacket and gear pack, daily excursions, all meals and beverages, gratuities and port charges, entertainment, and Wi-Fi.

2024 dates: The inaugural cruise sets sail on August 16, 2024.

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Viking River Cruises

Courtesy of Viking

Viking is no stranger to sailing Europe's rivers; the brand is synonymous with river cruising worldwide aboard its dozens of ships. However, Viking River Cruises is a newcomer to U.S. rivers, with its purpose-built ship: the 386-passenger Viking Mississippi. Looking to carve out its own niche in the American river cruising category, Viking claims it has the region's "first truly modern cruise ship" with its distinct Scandinavian design and expansive top sun deck with an infinity plunge pool.

Viking's mostly all-inclusive fares include a complimentary excursion in each port, destination lectures and performances, beer and wine at meals, free Wi-Fi, specialty coffees and teas, and more. The line offers five itineraries ranging in length from eight to 22 days along the Mighty Mississippi. Pre- and post-cruise extensions can be added to all voyages for an additional expense.

New Orleans & Southern Charms: Round-trip from New Orleans

Length: Eight days Price: Starts at $3,999 per person

If you don't know which Viking Mississippi itinerary to choose, start here. A round-trip voyage from New Orleans is convenient for booking flights and offers an excellent opportunity to extend your stay in NOLA. Six guided tours are included across eight days, from the historic estates of Natchez to Vicksburg National Military Park. A stop in St. Francisville gives you the chance to marvel at some of the 140-plus buildings it has on the National Register of Historic Places.

If you extend your stay in New Orleans, plan to sample the local Creole cuisine and take in some of the city's nightly jazz entertainment. In the morning, grab a beignet and a steaming cup of chicory coffee au lait at the original Café du Monde in the French Market.

2024 dates: This itinerary is available on select dates in February, November and December.

Heart of the Delta: New Orleans to Memphis

Length: Nine days Price: Starts at $4,299 per person

Similar to its round-trip New Orleans Southern Charms itinerary, the Heart of the Delta cruise begins in New Orleans and calls on the same five ports, before sailing through the Lower Mississippi and disembarking in Memphis. Enjoy scenic views of the serpentine river route – perhaps with expert commentary or a local cooking demonstration – and then take time to explore the birthplace of the Memphis blues, which is also a center of civil rights history.

2024 dates: In 2024, this cruise is available in February, March, April, May, June and November.

America's Great River: St. Paul to New Orleans

Length: 15 days Price: Starts at $12,999 per person

This Viking voyage sails from St. Paul to New Orleans on a two-week trip that calls on 13 ports with one day of scenic sailing. This itinerary combines the best of Viking's other Mississippi sailings for an all-encompassing Midwestern and Southern experience with 12 guided tours.

Included in the fare is a tour of Graceland; a stroll through small-town Burlington, Iowa, to see Snake Alley, deemed the most crooked street in the world; and a visit to the National Eagle Center of Red Wing, among others. For an additional fee, hop on an airboat ride through the Atchafalaya Swamp in Baton Rouge or tour the Anheuser-Busch Brewery of St. Louis.

2024 dates: Viking has availability for this itinerary in July, September and October.

Want to cruise the Mississippi River? See the top cruises on GoToSea , a service of U.S. News.

You may have seen riverboat gambling ships or are at least familiar with riverboat gambling along U.S. waterways. However, while high rolling on the river sounds like an exciting way to spend a night (or two, or more) while on your riverboat cruise, you'll have to jump ship to play the slots, roll the dice, spin the wheel or play a hand of Texas Hold 'em. Gambling on cruise ships sailing on internal waters is prohibited by U.S. law.

Gambling on boats in the U.S. is a complicated matter. While you will find some ships sailing along American waterways that are only set up for gambling, they are not carrying passengers from port to port. Most vessels that feature riverboat gambling are now moored, offering sports betting, table games, entertainment, live music and dancing while tethered to shore.

Why Trust U.S. News Travel

Gwen Pratesi has been an avid cruiser since her early 20s. She has sailed on nearly every type of cruise ship built, including the newest megaships, paddle-wheelers on America's waterways, and an 18-stateroom river ship on the Mekong River in Vietnam and Cambodia. Most recently, she traveled on a small luxury expedition vessel in Antarctica and crossed the notorious Drake Passage twice. She covers the travel and culinary industries, specializing in cruises, for major publications including U.S. News & World Report.

You might also be interested in:

• The Top River Cruise Lines
• The Top All-Inclusive Cruises
• Cruise Packing List Essentials
• The Top Cruise Insurance Plans

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• Explore the history, arts, and culture of Minneapolis, Minnesota
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Day 1: minneapolis, minnesota, day 2: red wing, minnesota | embark.

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Day 5: dubuque, iowa, day 6: bettendorf, iowa, day 7: burlington, iowa, day 8: hannibal, missouri, day 9: st. louis, missouri, day 10: river cruising, day 11: memphis, tennessee, day 12: port of the mississippi delta, day 13: vicksburg, mississippi, day 14: natchez, mississippi, day 15: nottoway, louisiana, day 16: new orleans, louisiana | disembark.

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Initial deposit is $250 per person, and most travelers will call our office and pay the deposit with a credit card.

Final payment is due 71 days prior to departure by MasterCard, Visa, Discover, Diners Club, or check

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The 7 Best Mississippi River Cruises for 2024

T he more than 2,300-mile Mississippi River invites travelers to discover its multifaceted heritage, with a vast range of deeply rooted culture, music and history. A cruise is a fantastic way to discover many of the riverfront cities on a single trip, from the comfort of your modern riverboat or traditional paddle-wheeler.

The following Mississippi River cruise itineraries can help you choose from cruises of various lengths and options for the Lower and Upper Mississippi. Note that all fares are listed as double occupancy (based on two people per cabin), and that they might not reflect taxes, port fees or gratuities. The itinerary availability listed is also subject to change.

American Cruise Lines

American Cruise Lines operates small ships accommodating between 90 and 180 passengers that are built, flagged and crewed in the U.S. – and it's the only company in the world operating a 100% U.S.-flagged fleet of riverboats and cruise ships. ACL's itineraries traverse waterways across 35 states, with 11 itineraries dedicated to the Mississippi River. Cruisers can choose to sail on modern riverboats with a sleek interior design or while away their time aboard classic paddle-wheelers reminiscent of days gone by.

ACL offers variety as well as versatility: This line boasts both the longest and shortest sailings on this list with cruises ranging from eight to 60 days in length, including The Great United States. This inaugural 60-day voyage spans four major rivers and 20 states, making it the longest U.S. river cruise in history.

Complimentary hotel and transportation packages are available from every departure city before your cruise. You can book certain premium packages for added perks, such as two nights spent next door to Graceland in Memphis – with VIP tickets and a city tour included in the price.

Music Cities Cruise

Length: Eight days

Price: Starts at $3,610 per person

Spend a week getting lost in the sounds of the Memphis blues, rock 'n' roll and country music legends on the seven-night Music Cities Cruise. A hotel stay the night before your sailing is included, but embarking in Memphis means you also have the chance to splurge on a two-night pre-cruise package near Elvis' former home Graceland .

Ports of call include Paducah, Kentucky; Dover, Tennessee; and Clarksville, Tennessee, with an overnight in Nashville and an included excursion to a show at the Grand Ole Opry. Two scenic sailing days feature picturesque views of America's Heartland along the Mississippi, Ohio and Cumberland rivers as well as Lake Barkley.

2024 dates: In 2024, there are two available itineraries in September and November.

Grand Heartland Cruise: St. Paul to New Orleans

Length: 15 days

Price: Starts at $9,455 per person

This 15-day voyage allows you to explore America's rich history in towns along the Upper and Lower Mississippi River. The immersive voyage covers six states and 12 cities including St. Paul, Minnesota ; Dubuque, Iowa; St. Louis, Missouri ; Memphis, Tennessee; Natchez, Mississippi; Baton Rouge, Louisiana ; and more.

Take a step back in time while visiting Mark Twain's boyhood home in Hannibal, exploring stately historic estates in Natchez and Civil War sites in Vicksburg. At the end of a busy day ashore, you'll have plenty to chat about with fellow passengers during the evening cocktail hour.

2024 dates: American Heritage – ACL's traditional paddle-wheeler – and three modern riverboats set off on this journey from August to October in 2024.

Complete Mississippi River Cruise: New Orleans to St. Paul

Length: 22 days

Price: Starts at $14,935 per person

If you want to see the entire Mississippi in one shot, check out this multiweek sailing that begins in New Orleans and ends in St. Paul, Minnesota. Along the way, you'll sail 1,393 miles, visit 10 states and experience a staggering 20 ports of call as you tour Louisiana and then head northbound to Minnesota.

In the South, walk the battlefields of the Civil War and sample delicious Southern barbecue before listening to the rhythms of jazz, the blues and rock 'n' roll. Then, explore the small and larger cities along the upper parts of the river. Remember to take time to gaze out at the picturesque scenery and the rolling farmlands of America's Midwest before disembarking in St. Paul.

2024 dates: Three of ACL's modern riverboats sail this itinerary in May, June and August in 2024.

The Great United States

Length: 60 days

Price: Starts at $51,000

This two-month long journey – the longest domestic itinerary ever created – will check all the boxes for U.S. history and Civil War buffs, music and nature lovers, culinary enthusiasts, and beer and distilled spirits aficionados alike as the ship traverses America's iconic waterways through 20 states and 50 ports of call.

This epic journey showcases the natural beauty and living history of the U.S. from sea to shining sea. The sailing embarks in Portland, Oregon , on the Pacific Coast before traveling east to the Atlantic shore along four major rivers that highlight some of the country's most stunning coastlines. Upon arrival in New York Harbor, guests will have an unforgettable view of one of the most iconic landmarks in the U.S.: the Statue of Liberty .

Passengers can follow in the footsteps of Lewis and Clark along the Snake and Columbia rivers; cruise along Ol' Man River in search of Mark Twain and Elvis; see the vibrant colors of fall during peak season on the Hudson River; and take in the coastal breezes (and fresh seafood) along New England's rocky coastline.

This curated adventure also includes two flights: Jackson, Wyoming , to New Orleans as well as St. Paul to Portland, Maine , plus a land package through Glacier , Yellowstone and Grand Teton national parks. All-inclusive pricing covers the pre-cruise hotel stay, all flights and hotels between cruise segments, an ACL jacket and gear pack, daily excursions, all meals and beverages, gratuities and port charges, entertainment, and Wi-Fi.

2024 dates: The inaugural cruise sets sail on August 16, 2024.

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Viking River Cruises

Viking is no stranger to sailing Europe's rivers; the brand is synonymous with river cruising worldwide aboard its dozens of ships. However, Viking River Cruises is a newcomer to U.S. rivers, with its purpose-built ship: the 386-passenger Viking Mississippi. Looking to carve out its own niche in the American river cruising category, Viking claims it has the region's "first truly modern cruise ship" with its distinct Scandinavian design and expansive top sun deck with an infinity plunge pool.

Viking's mostly all-inclusive fares include a complimentary excursion in each port, destination lectures and performances, beer and wine at meals, free Wi-Fi, specialty coffees and teas, and more. The line offers five itineraries ranging in length from eight to 22 days along the Mighty Mississippi. Pre- and post-cruise extensions can be added to all voyages for an additional expense.

New Orleans & Southern Charms: Round-trip from New Orleans

Price: Starts at $3,999 per person

If you don't know which Viking Mississippi itinerary to choose, start here. A round-trip voyage from New Orleans is convenient for booking flights and offers an excellent opportunity to extend your stay in NOLA. Six guided tours are included across eight days, from the historic estates of Natchez to Vicksburg National Military Park. A stop in St. Francisville gives you the chance to marvel at some of the 140-plus buildings it has on the National Register of Historic Places.

If you extend your stay in New Orleans, plan to sample the local Creole cuisine and take in some of the city's nightly jazz entertainment. In the morning, grab a beignet and a steaming cup of chicory coffee au lait at the original Café du Monde in the French Market.

2024 dates: This itinerary is available on select dates in February, November and December.

Heart of the Delta: New Orleans to Memphis

Length: Nine days

Price: Starts at $4,299 per person

Similar to its round-trip New Orleans Southern Charms itinerary, the Heart of the Delta cruise begins in New Orleans and calls on the same five ports, before sailing through the Lower Mississippi and disembarking in Memphis. Enjoy scenic views of the serpentine river route – perhaps with expert commentary or a local cooking demonstration – and then take time to explore the birthplace of the Memphis blues, which is also a center of civil rights history.

2024 dates: In 2024, this cruise is available in February, March, April, May, June and November.

America's Great River: St. Paul to New Orleans

Price: Starts at $12,999 per person

This Viking voyage sails from St. Paul to New Orleans on a two-week trip that calls on 13 ports with one day of scenic sailing. This itinerary combines the best of Viking's other Mississippi sailings for an all-encompassing Midwestern and Southern experience with 12 guided tours.

Included in the fare is a tour of Graceland; a stroll through small-town Burlington, Iowa, to see Snake Alley, deemed the most crooked street in the world; and a visit to the National Eagle Center of Red Wing, among others. For an additional fee, hop on an airboat ride through the Atchafalaya Swamp in Baton Rouge or tour the Anheuser-Busch Brewery of St. Louis.

2024 dates: Viking has availability for this itinerary in July, September and October.

Want to cruise the Mississippi River? See the top cruises on GoToSea , a service of U.S. News.

FAQ Module : Travel - Top Mississippi River Cruises FAQs

Why Trust U.S. News Travel

Gwen Pratesi has been an avid cruiser since her early 20s. She has sailed on nearly every type of cruise ship built, including the newest megaships, paddle-wheelers on America's waterways, and an 18-stateroom river ship on the Mekong River in Vietnam and Cambodia. Most recently, she traveled on a small luxury expedition vessel in Antarctica and crossed the notorious Drake Passage twice. She covers the travel and culinary industries, specializing in cruises, for major publications including U.S. News & World Report.

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Mississippi River Cruises

Stretching for 2,350 miles down the United States, from Minnesota's Lake Itasca to the Gulf of Mexico, our new cruises on the "Mighty Mississippi" offer a different type of cross-country journey for the curious explorer—one that allows you to be immersed in American history and culture.

Step on board the newest and most modern ship on the Mississippi with all outside staterooms, private verandas, spacious public areas and our signature, clean Scandinavian design, reimagined for the Mississippi River.

NEW! Mississippi Delta Explorer

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NEW! Heartland of America

America’s Heartland

New Orleans & Southern Charms

America’s Great River

NEW! Upper Mississippi Explorer

Grand Mississippi Voyage

NEW! The Big Easy to the Gateway City

NEW! Mississippi River Odyssey

Heart of the Delta

Highlights of mississippi river cruises.

A Mississippi River cruise offers the rare opportunity to sail through America's heartland on the world’s #1 river cruise line. Explore picturesque towns and boom cities; take in views of pastoral farms and towering bluffs; and immerse yourself in the region's rich history and culture with an included excursion in every port. Here are a few highlights Viking reveals to you:

• Festive French Quarter and Creole cuisine in New Orleans
• Cajun heritage in Baton Rouge
• Civil War history at Vicksburg National Military Park
• Memphis BBQ, Graceland and appreciation of the Delta Blues
• Steamboat sailings with diverse wildlife sightings
• Mark Twain's boyhood home and America’s literary history
• Up close look at America’s national symbol, the bald eagle
• Gateway Arch in St. Louis and the pioneering spirit of the Midwest
• Norwegian cultural experience at Vesterheim
• Intricate locks and dams of the Upper Mississippi

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