travel calm side effects

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Brand name: Travacalm Original TM

Active ingredients: dimenhydrinate + hyoscine hydrobromide + caffeine

What it is used for

For the prevention of travel sickness .

How to take it

The way to take this medicine is: Oral. This medicine is taken by mouth.

• Store below 30 degrees Celsius
• Protect from Light
• Protect from Moisture
• Shelf lifetime is 3 Years.

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.

Always read the label. If symptoms persist see your healthcare professional.

Visual appearance

Flat white tablet with a half score on one side. 9.0 mm diameter

Do I need a prescription?

What is the medicines and poisons schedule.

This medicine is available from a pharmacy without prescription. It is Schedule 2 : Pharmacy Medicine. open tool tip to find out more

This medicine contains the active ingredients:

• dimenhydrinate + hyoscine hydrobromide + caffeine

If you are over 65 years of age, there may be specific risks and recommendations for use of this medicine. Please discuss your individual circumstances with your pharmacist, doctor or health professional. For more information read our page on medication safety for older people .

Reporting side effects

You can help ensure medicines are safe by reporting the side effects you experience.

You can report side effects to your doctor, or directly at www.tga.gov.au/reporting-problems

Need more information?

These trusted information partners have more on this topic.

Top results

Travel sickness self-care - MyDr.com.au

Travel or motion sickness may occur in any type of moving vehicle, such as a car, boat or plane. Find out what products are available for travel sickness.

Read more on myDr website

Motion sickness - MyDr.com.au

Many people eventually grow out of motion sickness (travel sickness), but for those who don’t there are treatments available and things you can do to help prevent it and ease the symptoms.

Healthdirect Australia is not responsible for the content and advertising on the external website you are now entering.

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Hyoscine for travel sickness

Joy rides, kwells, scopoderm.

Peer reviewed by Sid Dajani Last updated by Michael Stewart, MRPharmS Last updated 21 Nov 2022

Meets Patient’s editorial guidelines

Follow the dosage directions on the label or pack. Do not take more than the recommended dose.

If you are taking tablets, take a dose about 30 minutes before you travel.

If you have been prescribed a patch, apply it to the skin behind your ear 5-6 hours before your journey starts.

Hyoscine may make you sleepy. If this happens, do not drive and do not use tools or machines.

In this article :

About hyoscine, before taking hyoscine, how to use hyoscine, getting the most from your treatment, can hyoscine cause problems, how to store hyoscine, important information about all medicines.

Continue reading below

Hyoscine is an effective medicine for travel sickness . It works by preventing the confusing messages going to your brain.

There are a number of different brands of tablet available which contain hyoscine as a salt, called hyoscine hydrobromide. You can buy these without a prescription at pharmacies. There are two strengths of tablets available: 300 microgram tablets for adults, and 150 microgram tablets for children. The dose for younger children will require halving a tablet.

There is also a product called Scopoderm® 1.5 mg patch. This is a patch for people aged 10 years or over. You stick the patch on to the skin behind your ear 5-6 hours before your journey, and then remove it at the end of the journey. The patch releases hyoscine through your skin and into your bloodstream.

One of the other effects of hyoscine is that it causes a dry mouth. It is sometimes prescribed by doctors for this reason, rather than to prevent travel sickness.

There is also a similar-sounding medicine called hyoscine butylbromide. This is an antispasmodic medicine which is used to relieve pain caused by tummy (abdominal) cramps. There is more information about this in a separate medicine leaflet called Hyoscine butylbromide tablets .

To make sure this is the right treatment for you, before you (or your child) start taking hyoscine, it is important that your doctor or pharmacist knows:

If you are pregnant or breastfeeding.

If you are unwell and have a high temperature (fever).

If you have digestive system problems such as reflux disease, diarrhoea, or ulcerative colitis.

If you have an eye condition called glaucoma.

If you have high blood pressure, a fast heart rate, or any other heart problems.

If you have problems with your liver, kidneys or prostate gland.

If you have epilepsy.

If you have a condition causing muscle weakness, called myasthenia gravis.

If you have Down's syndrome.

If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

If you have ever had an allergic reaction to a medicine.

Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about hyoscine, including a full list of the side-effects which you may experience from taking it.

Recommended doses are as follows:

For adults and children over 10 years of age: 150-300 micrograms.

For those aged 4-10 years: 75-150 micrograms.

For those aged 3-4 years: 75 micrograms.

You should take a dose of tablets 30-60 minutes before the start of the journey, and then repeat the dose after six hours if needed. There is a maximum number of tablets that can be taken in any 24-hour period, so remember to check the directions on the label carefully to make sure that you (or your child) do not take more than the recommended daily amount.

Read the label on the pack carefully to see whether the tablets should be sucked or chewed, or simply swallowed with a drink of water.

If you have been prescribed Scopoderm® 1.5 mg patches:

Stick one patch to the skin just behind your ear 5-6 hours before the start of your journey and remember to remove it after your arrival.

The effect of the patch can last up to 72 hours, so it is suitable for people taking long journeys.

Once removed, fold the patch in half so it sticks together and dispose of it carefully.

Remember to wash your hands after handling the patches, and also it is important to clean behind your ear after you have removed the patch. This is to make sure you remove any remaining traces of hyoscine from your skin.

Do not apply more than one patch at a time and do not cut the patches unless your doctor or a pharmacist tells you to.

Hyoscine can make you sleepy, and if you are using the patches, you may still feel sleepy the following day. If this happens, do not drive and do not use tools or machines until you feel well again. Also, avoid drinking alcohol, as this will increase the feelings of sleepiness.

When you buy any medicines, you should always check with a pharmacist that they are safe to take alongside your other medicines. This is particularly important with hyoscine because it can increase the side-effects from some other treatments.

Other things which can help to prevent travel sickness are:

Looking out of a window or sitting with your head tilted slightly backwards.

Taking regular breaks in your journey to have some fresh air and drink some cold water.

Breathing deeply and slowly while you listen to music.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with hyoscine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Important: on rare occasions more serious side-effects can occur when using hyoscine hydrobromide patches (Scopoderm ® patches). This is more likely if using the patches in a way the manufacturer did not intend, for example cutting patches or using more than one patch. People using hyoscine patches, or their carers, should be alert for signs that the dose is too high. These can include: a high temperature (fever), difficulty passing urine, confusion, disorientation, seeing or hearing things that are not there (hallucinations), fits or convulsions, reduced consciousness and difficulty breathing. If you notice any of these symptoms, remove the patch(es) immediately and seek medical help.

Keep all medicines out of the reach and sight of children.

Store in a cool, dry place, away from direct heat and light.

Never take more than the recommended dose. If you suspect that you or someone else has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.

If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Report side effects to a medicine or vaccine

If you experience side effects, you can report them online through the Yellow Card website .

Further reading and references

• Manufacturer's PIL, Kwells® Kids ; Dexcel Pharma Ltd, The electronic Medicines Compendium. Dated May 2022.
• Manufacturer's PIL, Kwells® 300 microgram tablets ; Dexcel Pharma Ltd, The electronic Medicines Compendium. Dated May 2022.
• Manufacturer's PIL, Joy-Rides® Tablets ; Teva UK Limited, The electronic Medicines Compendium. Dated October 2020.
• Manufacturer's PIL, Scopoderm® 1.5 mg Patch ; GlaxoSmithKline Consumer Healthcare, The electronic Medicines Compendium. Dated August 2021.
• Medicines Complete BNF 87th Edition ; British Medical Association and Royal Pharmaceutical Society of Great Britain, London.

Article History

The information on this page is written and peer reviewed by qualified clinicians.

Next review due: 20 Nov 2025

21 nov 2022 | latest version.

Last updated by

Peer reviewed by

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Travacalm Original

Generic Name: Caffeine; Dimenhydrinate; Hyoscine hydrobromide Product Name: Travacalm Original

Travacalm Original  is indicated for prevention of motion sickness in adults and children greater or equal to 4 years.

Dimenhydrinate, one of the active ingredients of Travacalm Original, is an antihistamine with central anticholinergic effects and is highly effective in the prevention of motion sickness.

Hyoscine hydrobromide also has strong anticholinergic effects.

Caffeine is used to counteract the sedative side effects of the other two ingredients, dimenhydrinate and hyoscine hydrobromide.

Dose advice

Dose information:

• Travacalm Original tablets may be taken with or without food.
• Travacalm Original tablets may be crushed and mixed with water, jam or honey before giving to children or those with swallowing difficulties.
• Travacalm Original is most effective when use for prevention but may have some effectiveness once symptoms are present.
• Travacalm Original may cause drowsiness. If you are affected, do not drive or operate machineries as your alerness may be compromised.
• Avoid drinking alcohol or other medications that may potentiate the sedating effects of Travacalm Original.

Contraindications:

Travacalm Original should not be used

• if you have known allergy to active ingredients of Travacalm Original, dimenhydrinate, hyoscine hydrobromide, caffeine
• in children under 2 years old
• if you are lactose intolerant

Precautions:

You must tell your doctor if you

• have glaucoma
• have emphysema
• have chronic pulmonary disease
• have shortness of breath
• have difficulty in breathing
• have difficulty in urination due to enlargement of the prostat gland
• have urinary retention
• have acute porphyria
• have epilepsy or seizure disorders
• are taking any other medicines, including those that you buy without a prescription from your pharmacy, supermarket or health food store
• are pregnant
• are breasfeeding or intend to breastfeed

Use in pregnancy ( Category B2 ):

Despite it is consider safe to use Travacal original during pregnancy, you should check with your doctor before using Travacalm Original.

Small amounts of Travacalm Original active ingredients are excreted in breast milk. Travacalm Original should not be given to breastfeeding mothers unless the benefits of therapy outweigh the potential risks.

Travacalm Original is Schedule 2 .

Common side effects

All medicines have side effects. Most commonly the side effects are minor, however some can be more serious. Usually the benefits of taking a medication outweigh the associated side effects. Your doctor would have considered these side effects before starting you on Travacalm original.

Common side effects are those which occur in more than 1% of patients given Travacalm Original. These include:

• Blurred vision
• Incoordination
• Palpitations
• Low blood presure

Uncommon side effects

Side effects which occur in less than 0.1% of patients given Travacalm original are considered uncommon. If you experience any of the listed side effects, or any other symptoms which appear abnormal or unusual, please tell your doctor.

• blood dyscrasias (prolonged therapy)
• fixed drug erruption
• Australian Medicines Handbook. Dimenhydrinate. January 2008 [cited 2008 September 7]. Available from: [ URL Link ]
• Australian Medicines Handbook. Hyoscine hydrobromide. January 2008 [cited 2008 September 7]. Available from: [ URL Link ]
• MIMS Online. Travacalm Original. [cited 2008 September 7]. Available from: [ URL Link ]

For further information talk to your doctor.

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• » Summaries of medicine characteristics
• » TRAVEL CALM TABLETS - summary of medicine characteristics

TRAVEL CALM TABLETS - summary of medicine characteristics

Dostupné balení:

Table of contents

Sources: Original (products.mhra.gov.uk)

Summary of medicine characteristics - TRAVEL CALM TABLETS

1 name of the medicinal product.

Travel Calm Tablets

2. QUALITATIVE AND QUANTITATIVE COMPOSITION

Active ingredient                  m­g/tablet

Hyoscine hydrobromide          300 micrograms

3. PHARMACEUTICAL FORM

4. CLINICAL PARTICULARS

4.1. Therapeutic Indications

For the prevention and relief of travel sickness.

4.2. Posology and Method of Administration

Adults and children over 12 years: One tablet.

Children 7 to 12 years: Half a tablet.

Children 3 to 7 years: Quarter of a tablet.

Not to be taken by children under 3 years.

Elderly: The normal adult dose is still appropriate in the elderly.

The dose should be taken 20 minutes before the journey and may be repeated in 6–8 hours if necessary.

Not more than three doses to be taken in 24 hours.

For oral administration.

4.3. Contra-Indications

Prostatic enlargement, paralytic ileus, pyloric stenosis, closed angle glaucoma.

4.4 Special warnings and precautions for use

Should be used with caution in conditions characterised by tachycardia such as thyrotoxicosis and cardiac failure. Should be used with caution by elderly patients and in patients suffering from impaired renal, hepatic or metabolic function.

Warning: May cause drowsiness. If affected do not drive or operate machinery. Avoid alcoholic drink.

There have been rare reports of an increase in frequency of seizures in epileptic patients.

Keep all medicines out of the reach of children.

4.5. Interaction with other Medicinal Products and other Forms of Interaction

The effects of hyoscine may be enhanced by other drugs with anticholinergic properties, including amantadine, some antihistamines, butyrophenones, phenothiazines and tricyclic antidepressants. Patients should also avoid alcohol. The reduction in gastric motility caused by hyoscine may also affect the absorption of other drugs.

4.6. Pregnancy and Lactation

The safety of hyoscine during pregnancy and lactation has not been established, although there is no definite evidence of adverse consequences if taken during early pregnancy. No significant quantities of hyoscine were found in milk when the drug was given to lactating women. Nevertheless, the product should not be used during pregnancy, unless the expected benefit is thought to outweigh any possible risk to the foetus.

4.7. Effects on Ability to Drive and Use Machines

Hyoscine may cause drowsiness and dulling of mental alertness and therefore those taking this medication should not take charge of motor vehicles or operate machinery.

4.8 Undesirable effects

Side effects may include drowsiness, dryness of the mouth, thirst, reduced bronchial secretions, mydriasis, loss of accommodation, photophobia, increased intra-ocular pressure, flushing, dry skin, bradycardia followed by tachycardia, with palpitations and arrhythmias, difficulty in micturition, reduction in tone and motility of the gastrointestinal tract leading to constipation. Occasionally vomiting, giddiness and staggering may occur. There have also been occasional reports of confusional states and hallucinations when given to children.

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard .

4.9. Overdose

Symptoms of overdo sage may include any of the undesirable effects mentioned above under section 4.8 and tachycardia, rapid or stertorous respiration, hyperpyrexia, restlessness, confusion and excitement, hallucinations and delirium. In severe cases, depression of the central nervous system may occur with coma, circulatory and respiratory failure and death.

Treatment consists of emptying the stomach by lavage and aspiration. Charcoal may be used to prevent further absorption. Give a saline purgative, such as sodium sulphate 30g in 250ml of water.

Peripheral anticholinergic effects may be controlled by the administration of the antichlolines­terase, neostigmine. Excitement may be controlled by diazepam. Otherwise treatment should be symptomatic and supportive.

5. PHARMACOLOGICAL PROPERTIES

5.1. Pharmaco­dynamic Properties

Hyoscine is an anticholinergic agent with central and peripheral actions.

5.2. Pharmacokinetic Properties

Hyoscine hydrobromide is readily absorbed from the gastrointestinal tract. It Is almost entirely metabolised, probably in the liver. Only a small proportion of an oral dose is excreted unchanged in the urine. Hyoscine crosses the placental barrier and traces may appear in milk.

5.3. Pre-clinical Safety Data

There are no preclinical data of relevance to the prescriber which are additional to that already included.

6. PHARMACEUTICAL PARTICULARS

6.1. List of Excipients

Dextrose monohydrate

Purified water

Stearic acid

Magnesium stearate

6.2. Incompatibilities

Not applicable.

6.3. Shelf-Life

6.4 special precautions for storage.

Do not store above 30oC.

6.5. Nature and Content of Container

PVC blister tray heat-sealed to hard temper aluminium foil containing 12 tablets.

6.6. Instructions for Use, Handling and Disposal

7. MARKETING AUTHORISATION HOLDER

The Boots Company PLC

1 Thane Road West

8. MARKETING AUTHORISATION NUMBER(S)

PL 00014/5369R

9. DATE OF FIRST AUTHORISATION / RENEWAL OF AUTHORISATION

15 June 1990

Medine.co.uk

Travel calm tablets.

120 mm 120 mm

J^jjjjjjjjjj     Information for the user

(Hyoscine Hydrobromide)

Read all of this leaflet carefully because it contains important information for you.

] This medicine is available without i prescription to treat minor conditions.

| However, you still need to take it carefully to ' get the best results from it.

! • Keep this leaflet, you may need to read it ] again

i • Ask your pharmacist if you need more | information or advice

| What this medicine is for

! This medicine contains Hyoscine | Hydrobromide which belongs to a group of i medicines called anticholinergics.

| It can be used to prevent and relieve the ' unpleasant effects of travel sickness.

: Before you take this < medicine

! This medicine can be taken by adults and ] children aged 3 years and over. However,

! some people should not take this medicine | or should seek the advice of their i pharmacist or doctor first.

A Do not take:

| • If you are allergic to any of the ingredients I • If you have glaucoma  ; • If you have stomach problems or a

i blockage in your intestine | • If you are a man with prostate problems i • If you have an intolerance to some I sugars, unless your doctor tells you to (this ] medicine contains glucose) i • If you are pregnant, unless your doctor | tells you to

! Talk to your pharmacist or doctor:

•    If you have heart failure, or a fast heart beat !

•    If you have kidney or liver problems    |

•    If you have an overactive thyroid

•    If you have problems with your metabolism j

•    If you are elderly

•    If you are breastfeeding    |

Other important information;

Driving and using machines: This medicine may cause drowsiness. If affected do not I drive or operate machinery.    |

Do not drink alcohol (e.g. wine, beer, i spirits) whilst taking this medicine.    |

If you take other medicines j

Before you take these tablets, make sure that you tell your pharmacist about ANY other | medicines you might be using at the same time, particularly the following:    I

•    Other anticholinergic medicines (e.g.    ]

amantidine for Parkinson’s disease)

•    Antihistamines (for treating allergy or hayfever)

•    Butyrophenones, phenothiazines (for

mental problems)    I

•    Tricyclic antidepressants    |

If you are unsure about interactions with any i other medicines, talk to your pharmacist. Thisj includes medicines prescribed by your doctor and medicine you have bought for yourself, I including herbal and homeopathic remedies. 1

How to take this medicine

I Check the foil is not broken before use. If it | is, do not take that tablet.

I Chew or swallow the first tablet (or part j tablet) twenty minutes before your journey i begins.

Do not give to children under 3 years.

Do not take more than the amount recommended above.

f If you take too many tablets: Talk to your doctor or go to your nearest hospital casualty department. Take the medicine and this leaflet with you.

Possible side effects

Most people will not have problems, but some may get some of these:

•    Drowsiness, giddiness, staggering

•    Dry mouth or nose, thirst, dry skin, difficulty in passing urine

•    Increased pressure in the eye, dislike of bright light, widening of the pupils in the eye, changes in the muscles in the eye

•    Changes in heart rate, fast, irregular heart beat

•    Constipation, being sick

•    Increased number of fits if you have epilepsy

•    Occasionally, hallucinations and confusion,

_ particularly jn chijdren _

Reporting of side effects

If you get any side effects, talk to your doctor,i pharmacist or nurse. This includes any j possible side effects not listed in this leaflet. ' You can also report side effects directly via | the Yellow Card Scheme at:     1

www.mhra.aov.uk/vellowcard . By reporting I side effects you can help provide more j information on the safety of this medicine, i

How to store this medicine !

Keep this medicine in a safe place out of the I sight and reach of children, preferably in a j locked cupboard.    i

Use by the date on the end flap of the carton, j Do not store above 30°C.

What is in this medicine

Each tablet contains Hyoscine Hydrobromide i 0.3 mg, which is the active ingredient. As well as| the active ingredient, the tablets also contain i glucose, stearic acid, magnesium stearate.    j

The pack contains 12 round white tablets. ' The tablets are scored on one side into a cross | shape so that it can be broken into quarters, j

Who makes this medicine

Manufactured for the Marketing Authorisation! holder The Boots Company PLC Nottingham! NG2 3AA by Bristol Laboratories Ltd    j

Northbridge Road Berkhamsted Herts    I

HP41EG    |

Leaflet prepared January 2015    i

If you would like any further information about; this medicine, please contact    i

The Boots Company PLC Nottingham    j

Other formats

To request a copy of this leaflet in Braille, 1 large print or audio please call, free of charge: I  0800 198 5000 (UK only)    |

Please be ready to give the following     1

information:    I

Product name: Boots Travel Calm Tablets 1 Reference number: 00014/5369    !

This is a service provided by the    j

Royal National Institute of Blind People.    i

ARTWORK ONLY

ARTWORK TEXT SIZE

Main Headings:     13pt

Sub Headings:     11 pt

Body Copy:     9pt

Travel sickness self-care

by myDr | Pharmacy Care , Travel Health

General Information

See your pharmacist or medical professional, treatment tips, treatment options, more information.

Travel or motion sickness may occur in any type of moving vehicle, such as a car, boat or plane.

It may be due to either an over-stimulation of the balance mechanisms located within the inner ear, or to a temporary inability of the brain to process conflicting information arising from the various sensory systems monitoring balance within the body.

The sensory systems involved are:

• inner ears, which monitor the direction of motion
• eyes, which monitor where the body is and the direction of motion
• skin pressure sensors, which monitor what parts of the body are touching the ground
• muscles and joint sensors, which monitor what parts of the body are moving

For example, in a boat tossed about by waves, your ears and skin detect that you are moving, but your eyes are focused on the cabin wall. Signals from your inner ears, skin, and eyes are in conflict, and this is what makes you feel sea-sick.

Children aged 2 to 12 years are more likely to have travel sickness than adults and younger children. Women are more susceptible to travel sickness than men; this may be related to hormonal changes during pregnancy and menstruation.

Having a stomach filled with fatty, spicy food and fizzy or alcoholic drinks can make someone more likely to feel sick during travel. Feeling anxious, tired or unwell can also increase the risk of travel sickness. Some people develop a conditioned response, so that even just sitting in a car can make them feel sick.

Once the person with travel sickness has vomited, they normally feel better, although symptoms may return and become more severe. After a few days of exposure to the motion, such as on a boat, people will adapt. Symptoms of travel sickness can settle down and even disappear.

Travel sickness tends to improve once you reach your destination; however, it may take a few hours or days to improve completely, as you will need to re-adapt to the lack of movement once motion stops.

Symptoms of travel sickness

• hyperventilating (rapid, deep breathing)
• looking pale
• producing more saliva than normal
• if you have stomach discomfort, nausea or vomiting – especially if these symptoms persist after travel is completed
• if you have become pale, especially in the face
• if you are sweating, or feeling hot
• if you have goose pimples and are feeling cold
• if you feel dizzy, faint or have an ear infection or ear pain
• if you feel sick when you move your head
• if the person with travel sickness is a child, and they have become quiet and withdrawn
• if you have severe anxiety associated with travel, such as fear of flying, which may require specialist counselling
• if your symptoms have become worse over time
• if you are pregnant or breastfeeding; some products may not be suitable for you (ask your pharmacist)
• if you have other medical conditions (e.g. glaucoma, epilepsy or heart disease), or take other medicines, such as for depression; some products may not be suitable for you (ask your pharmacist)
• if you have problems urinating or prostate problems; some products may not be suitable for you (ask your pharmacist)
• if you have allergies to any medicines
• the best way to treat travel sickness is to prevent it
• avoid heavy, fatty and spicy meals and alcohol before travelling
• a light, simple meal about one hour before travel is best. Glucose, such as lollies or lemonade and biscuits, are useful snacks
• peppermint or ginger taken an hour before travel may help
• stay calm and relaxed before travel and, if possible, stop for breaks during the trip
• sit in the most stable area to keep motion at a minimum, such as over an aeroplane wing, in the front seat of a car, or on a ship’s deck
• sit facing in the direction you are travelling, so that a distant, stable reference point can be seen, such as the road ahead or the horizon
• lie down (if possible), use a head support and close your eyes to reduce head movement
• avoid activities, such as reading, that encourage looking down and require close visual concentration
• listen to music or do something to distract you
• get plenty of fresh air if possible (open personal air vents on planes)
• make sure you have plenty of sick bags in case you vomit
• bring an oral rehydration solution as a precaution for dehydration caused by vomiting
• medicines are more effective if you use them to prevent travel sickness. They can be taken from 30 minutes to 2 hours before travel. Some can be taken up to 5 to 6 hours before travel, or the night before
• some preparations are not suitable for children; check manufacturer’s directions. Sedating antihistamines should not be used for the prevention and treatment of motion sickness in children under the age of 2 and should be used with caution in older children.
• side effects of medicines for travel sickness may include drowsiness, blurred vision, dry mouth, constipation and confusion; stop taking the medicine if you experience any of these and they bother you
• do not drink alcohol with medicines that make you drowsy
• young children and elderly people are more sensitive to side effects of medicines. Rarely, some travel sickness medicines cause children to become over-excited; stop using the medicine if this happens

[PHARMACY ONLY] e.g. hyoscine hydrobromide (Kwells, Travacalm HO)

• make sure the correct dose is used according to the age of the person (check product instructions)
• hyoscine hydrobromide has a shorter duration of action therefore is recommended for shorter journeys
• the first dose should be taken 30 minutes before travel
• this medication may cause drowsiness

Antihistamines

[PHARMACY ONLY]

e.g. promethazine theoclate (Avomine) 10 pack

[PHARMACIST ONLY] e.g. promethazine hydrochloride ( Phenergan )

• promethazine needs to be taken 1 to 2 hours prior to travel and is useful for longer travel times
• this medication will cause drowsiness
• should not be used if you are doing any water activities, such as deep-water diving, or you will be operating heavy machinery

Combination products

[PHARMACY ONLY] e.g. hyoscine hydrobromide, dimenhydrinate, caffeine (Travacalm Original)

Acupressure wrist bands

[GENERAL SALE] e.g. Sea-Band

• these bands are placed on acupressure points on your wrists to help reduce feelings of nausea related to travel
• there have been reports of success; however, this depends on correctly placing the bands
• they can be used by people of all ages and during pregnancy

Other products

[GENERAL SALE] e.g.ginger (Travacalm Natural, Blackmores Travel Calm Ginger)

• does not cause drowsiness and is a more suitable option in pregnancy at the recommended dose

Availability of medicines

• GENERAL SALE available through pharmacies and possibly other retail outlets.
• PHARMACY ONLY available for sale through pharmacies only.
• PHARMACIST ONLY may only be sold by a pharmacist.

Search myDr for Consumer Medicine Information

Popular Reads

The Best Sleeping Pills for Flights—And When You Should Take Them

By Moira Lawler

If  noise-canceling headphones  don’t help you doze off, you may need to consider a more heavy-duty fix: sleeping pills for flights. Certainly, some flights don’t warrant sleeping aids—such as when you’re taking a short trip or traveling west against a time difference, says Aneesa Das, M.D. , a sleep medicine specialist at the Ohio State University (at that point you may as well stay awake). But if you’ll be on a plane overnight and waking up in a vastly different time zone, logging some shuteye on the plane is crucial to arriving refreshed—or close enough to it.

That’s when sleeping pills can help. For most people, they're a reliable solution if they have trouble sleeping on planes , and they’re always a better option than ordering wine when the beverage cart rolls around. “Alcohol will allow you to fall asleep more quickly, however most people will then experience very disrupted and fragmented sleep quality,” says Thomas Kilkenny, M.D. , director of the Institute of Sleep Medicine at Staten Island University Hospital.

Here's what you should know—according to medical experts—about the most common sleeping pills for flights, including side effects to be aware of before you pop one.

This article has been updated with new information since its original publish date.

Ambien—the most powerful option on this list—is available by prescription only and works as a  sedative-hypnotic medication  that slows your brain activity to make you feel very sleepy. It’ll knock you out good—maybe even  too  good. Some users experience retroactive amnesia, which means you could wake up mid-flight, have a full conversation with the  flight attendant , and have no memory of it when morning comes, Das says.

Ambien can also lead to sleepwalking, which could result in some awkward bump-ins on the plane. “This is especially true if combined with alcohol or if not enough time is allowed for sleep,” Kilkenny says. He recommends having at least six or seven hours to sleep in order for the drug to metabolize, so avoid taking it on a short flight or when you have only a few hours to go before landing. But it's not all bad: Zolpidem (the generic name for Ambien) has been shown to fight off jet lag, per a 2018 review article published in Springer . Lunesta and Sonata are two other prescription-only sleep aids which work similarly to Ambien (they’re collectively known as Z-drugs).

Rozerem (the brand name for ramelteon) is another medication available by prescription, but it isn’t as aggressive as Ambien. “It’s a melatonin receptor stimulant and is unrelated to the Z-pills,” Kilkenny says. It may be a more attractive option for travelers as it reaches peak levels quickly and has a very short half-life, which means it won’t linger in your system as long. You’ll want to take an 8 milligram (mg) dose 30 minutes before you want to doze off. It likely won’t knock you out as well as Ambien, but research published in the Journal of Central Nervous System Disease in 2011 suggests that it will regulate your sleep-wake cycle to help your circadian rhythm adjust to a new time zone. Plus, it doesn’t come with the nasty side effects of the Z-drugs, Kilkenny says.

The over-the-counter medication is easy to pick up at the drugstore when you’re stocking up on travel-sized shampoos and other carry-on essentials . Diphenhydramine, the same antihistamine found in Benadryl, will likely put you to sleep, though you may pay the price once you land. “It makes us feel really groggy when we wake up, and it can make us feel really hungover,” Das says. The antihistamine may also leave you with a dry mouth that those tiny airplane cups of water just can’t quench (not a good situation since flying in general can make you dehydrated). Still, Das says it’s okay to take so long as you’ve tolerated it in the past.

This hormone occurs naturally in the body, but taking an extra dose helps induce sleep and  adjust your circadian clock . That will help you function better at your destination and decrease the effects of jet lag, Kilkenny says. Start taking melatonin a few days before your trip, about four to six hours before your bedtime, so that you’re ready to hit the pillow 30 minutes to an hour earlier than normal, Das says.

A  2002 review from UK researchers  found melatonin decreases jet lag if you take it close to your target bedtime at your destination, especially if you’re traveling across five or more time zones. The researchers found doses of 0.5 and 5 mg were equally effective at  preventing jet lag , though the larger (maximum) dose will help you fall asleep quicker and sleep better.

Another plus? There are no major side effects to worry about—melatonin shifts the circadian rhythm with minimal side effects, the Springer article found. (Note: The FDA does regulate dietary supplements such as melatonin, but these regulations are less strict than those for prescription or over-the-counter medications. Check with your doctor for an appropriate recommendation.)

No matter which medication you decide to go with (if any), there are a few ground rules to follow. First, give it a test run at home. “You want to know how your body tolerates it before you go,” Das says. Then, once you’re settled into your seat, remember to  pass on booze  and don’t pop the medicine until the flight attendants have gone over  safety instructions .

Condé Nast Traveler does not provide medical advice, diagnosis, or treatment. Any information published on this website or by this brand is not intended as a substitute for medical advice, and you should not take any action before consulting with a healthcare professional.

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TravaCalm Ginger

TravaCalm Ginger reduces symptoms of travel sickness, including nausea. It is a non-drowsy formula containing ginger, with no added sugar, lactose, yeast, starch and artificial flavouring.

Suitable for adults and children 6 years and over.

Take 30 minutes before departure.

• Adults: First dose 2 or 3 tablets. Then 1 tablet every 2 hours as required.
• Children 6-12 years: First dose 1 tablet. Then 1 tablet every 4 hours as required.
• Children under 6 years: As professionally directed.

INGREDIENTS

Active Ingredient per tablet:

• Zingiber officinale root extract dry conc. 10 mg equiv. to root dry 100 mg
• Zingiber officinale dry root powder 400 mg

No added sugar, lactose, yeast, starch or artificial flavouring.

Q. When should I take TravaCalm Ginger for motion sickness? A. Take the first dose 30 minutes before departure to reduce symptoms of motion sickness, including nausea. If you suffer from motion sickness, or think that you may experience motion sickness, it’s best to take TravaCalm Ginger before you travel, that is, before you experience any symptoms of motion sickness.

Q. Can TravaCalm Ginger be used by children? A. TravaCalm Ginger can be given to children 6 years of age and older.

Q. Can TravaCalm Ginger cause drowsiness? A. TravaCalm Ginger is a non-drowsy formula.

Products in the same range

TravaCalm Travel Band

TravaCalm Original

Who can and cannot take hyoscine hydrobromide - Brand names: Kwells, Joy-Rides, Kwells Kids, Travel Calm, Scopoderm

Who can take hyoscine hydrobromide.

Hyoscine hydrobromide travel sickness tablets can be taken by most adults and children from the age of 3 years.

Patches for travel sickness can be used by most adults and children from the age of 10 years.

Who may not be able to take hyoscine hydrobromide

Hyoscine hydrobromide is not suitable for some people. To make sure it's safe for you, tell a pharmacist or doctor before taking it if you:

• have ever had an allergic reaction to hyoscine hydrobromide or any other medicine
• have an eye problem called primary angle closure glaucoma
• have difficulty peeing or a bowel blockage
• have myasthenia gravis , a condition that causes muscle weakness
• have heart problems, including a very fast heart rate
• have thyroid, kidney or liver problems
• have epilepsy (seizures)
• have digestive problems, such as acid reflux or severe constipation
• have ulcerative colitis
• have a high temperature
• are pregnant or trying to get pregnant, as hyoscine hydrobromide is not recommended in pregnancy

Page last reviewed: 5 October 2022 Next review due: 5 October 2025

Calm-Aid Side Effects

Generic name: diphenhydramine

Medically reviewed by Drugs.com. Last updated on Oct 3, 2023.

Note: This document contains side effect information about diphenhydramine. Some dosage forms listed on this page may not apply to the brand name Calm-Aid.

Applies to diphenhydramine : oral capsules and tablets, parenteral injection .

Side effects include:

Sedation, sleepiness, dizziness, disturbed coordination, epigastric distress, thickening of bronchial secretions.

For Healthcare Professionals

Applies to diphenhydramine: compounding powder, injectable solution, oral capsule, oral disintegrating strip, oral liquid, oral tablet, oral tablet chewable, oral tablet disintegrating .

The most commonly reported side effects included somnolence, dizziness, and incoordination. [ Ref ]

Nervous system

Common (1% to 10%): Sedation/somnolence/sleepiness, drowsiness, unsteadiness, dizziness, headache , attention disturbance

Rare (0.01% to 0.1%): Extrapyramidal effects, tremor, convulsions

Frequency not reported : Paresthesia, dyskinesia/muscle dyskinesia, vertigo, neuritis, incoordination, psychomotor impairment, activation of epileptogenic foci [ Ref ]

Drowsiness usually diminishes after a few days. [ Ref ]

Gastrointestinal

Common (1% to 10%): Dry mouth

Frequency not reported : Gastrointestinal disturbance, nausea, vomiting , constipation , diarrhea , dyspepsia , epigastric distress [ Ref ]

Common (1% to 10%): Fatigue

Frequency not reported : Lassitude, tinnitus, acute labyrinthitis, asthenia, chills, impaired performance (including impaired driving, work, and/or information processing) [ Ref ]

Psychiatric

Rare (0.01% to 0.1%): Confusion, depression , sleep disturbances

Frequency not reported : Paradoxical excitation/excitation, agitation, increased energy, restlessness, nervousness, euphoria, anxiety, hallucinations, insomnia, irritability [ Ref ]

Cardiovascular

Rare (0.01% to 0.1%): Palpitations , hypotension , arrhythmia

Frequency not reported : Tachycardia , chest tightness, extrasystoles [ Ref ]

Hematologic

Rare (0.01% to 0.1%): Blood disorders

Frequency not reported : Hemolytic anemia , thrombocytopenia , agranulocytosis [ Ref ]

Hypersensitivity

Rare (0.01% to 0.1%): Hypersensitivity reactions

Frequency not reported : Angioedema , anaphylactic shock [ Ref ]

Rare (0.01% to 0.1%): Liver dysfunction [ Ref ]

Dermatologic

Frequency not reported : Rash, urticaria , skin rashes, erythema, photosensitivity, pruritus , drug rash, excessive perspiration [ Ref ]

Respiratory

Frequency not reported : Dyspnea, thickening of bronchial secretions, throat tightening, wheezing , nasal stuffiness, dry nose or throat [ Ref ]

Genitourinary

Frequency not reported : Urinary hesitancy/difficulty/retention, dysuria, early menses [ Ref ]

Frequency not reported : Blurred vision, dry eyes, diplopia [ Ref ]

Frequency not reported : Increased appetite, anorexia [ Ref ]

Musculoskeletal

Frequency not reported : Muscle twitching/weakness [ Ref ]

Frequently asked questions

• What is the max dose of diphenhydramine for adults?
• Does Mucinex help with Covid?
• Does diphenhydramine raise blood pressure?
• Can diphenhydramine be used as a sleep aid?
• Does Benadryl help with or cause anxiety?
• Diphenhydramine Hydrochloride vs Citrate: What's the difference?

More about Calm-Aid (diphenhydramine)

• Check interactions
• Compare alternatives
• Latest FDA alerts (2)
• Dosage information
• During pregnancy
• Drug class: anticholinergic antiemetics
• Breastfeeding

Patient resources

Other brands.

Benadryl , Banophen , Benadryl Allergy , ZzzQuil , ... +24 more

Professional resources

• DiphenhydrAMINE monograph
• Diphenhydramine Oral Solution (FDA)

Benadryl , Benadryl Allergy , Diphen , Dicopanol

Related treatment guides

• Allergic Reactions
• Allergic Rhinitis
• Cold Symptoms

1. Product Information. Benadryl (diphenhydramine). Parke-Davis. 2002;PROD.

2. Product Information. Benadryl Children's Allergy Fastmelt (diphenhydrAMINE). Pfizer U.S. Pharmaceuticals Group. 2022.

3. Cerner Multum, Inc. UK Summary of Product Characteristics.

4. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA .

Medical Disclaimer

Use these dosage charts for infants and children under 12 years old:

• Benadryl Dosage Charts (Infants & Children)

Quviviq , prednisone , ondansetron , hydroxyzine , fluticasone nasal , montelukast , benzonatate , lorazepam , cetirizine , triamcinolone